Age

18–75

Sex

ALL

Healthy volunteers

Accepted

Age ≥18 and ≤75 years
Age, pack years, FEV1/FVC and FEV1% predicted must fit in one of the 9 groups of the study population
Physically and mentally able to undergo the total study protocol
Written informed consent

Participation in another study
Alpha-1-antitrypsin deficiency
Selected grade 1-3 co-morbidity listed in the ACE-27
Active pulmonary infection like tuberculosis, pneumonia, flue, tracheobronchitis
Active extra-pulmonary infection like hepatitis A-C, cystitis, gastro-enteritis etc
Pulmonary diseases like sarcoidosis, pulmonary fibrosis, silicosis, hypersensitivity pneumonitis, asthma
Life threatening diseases like carcinoma, AIDS (including HIV+), acute leukaemia etc
Medication that may affect the results of the study: NSAID's, immunosuppressive agents like prednisolon, metotrexate, azathioprine

Systemic Inflammation in Chronic Obstructive Pulmonary Disease (COPD)