Quality of Life in Patients With Statin-Associated Myopathy

Exclusion Criteria

• •concomitant treatment with other lipid-lowering agents
• •impaired liver or kidney function ( alanine aminotransferase (ALT) or asparate aminotransferase (AST) ≥ 3x upper limit of normal, creatinine ≥ 3x or creatine phosphokinase (CPK) ≥ 5x upper limit of normal)
• •untreated hypo or hyperthyroidism
• •current treatment with other medications known to increase risk of myopathy (e.g. cyclosporine, azithromycin, erythromycin and other macrolide antibiotics, azole antifungals, fusidic acid, digoxin)
• •documented history of muscle disorder or myopathy other than statin-associated myopathy
• •anemia (Hb\< 110 g/dL)
• •cancer within 5 years of enrollment except basal or squamous cell carcinoma (CA) of the skin
• •diabetes
• •HIV-1 infection
• •Uncontrolled blood pressure ≥ 160/100
• •known coronary artery disease or peripheral vascular disease
• •chronic illnesses such as lupus, rheumatoid arthritis, psoriasis
• •any condition, that at the investigators' discretion would impact/ bias the study data
• •long term oral, nasal, or inhaler steroid use \> 6 months
• •on Hormone Therapy except for thyroid replacement
• •alcohol consumption ≥ 40 g/day (3 glasses/day wine or beers or binge drinking ≥ 4 glasses/night)
• •engaged in significant amounts of sport or strenuous leisure activity (\> 60 min four times per week)
• •surgery in the past 6 months except for minor excision/incision procedures,
• •12-L electrocardiogram demonstrating old/new myocardial infarction/ ischemia or other findings that, at the cardiologist's discretion, may put the subject at high risk
• •cognitive impairment that prevents comprehension of questionnaires
• •inability to read English (questionnaire language)
• •Exclusions for the metabolic study:
• •currently taking beta blockers
• •body mass index \> 28 kg/m2
• •premenopausal females \< 50 yrs (menopause defined as 12 consecutive months without menstruation (in order to avoid the confounding effect of the menstrual cycle phase on fuel selection)
• •physical disability or previous injury that prevents safe exercise testing
• •do not meet the magnetic resonance spectroscopy (MRS) prescreening criteria