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MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation. miRNAs bind to their target messenger RNAs (mRNAs), leading to cleavage or suppression of target mRNA translation based on the degree of complementarity. miRNAs have recently been shown to play pivotal roles in diverse developmental and cellular processes and linked to a variety of skin diseases and cancers. In the present study the expression profiles for the two most important miRNA processing enzymes Dicer and Drosha of actinic keratoses, basal cell carcinoma and squamous cell carcinoma are compared to healthy skin tissue.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Department of Dermatology and Allergology, Ruhr-University Bochum
Bochum, Germany
Start Date
July 1, 2008
Primary Completion Date
February 1, 2009
Completion Date
February 1, 2009
Last Updated
October 16, 2012
28
ACTUAL participants
Lead Sponsor
Ruhr University of Bochum
NCT05702398
NCT07266142
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
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View ClinicalTrials.gov Terms and ConditionsNCT04844528