EMD 525797 in Colorectal and Ovarian Cancer Patients With Liver Metastases

Exclusion Criteria

• •Any systemic cancer treatment within 30 days before treatment with EMD 525797
• •Thrombolytics or oral or parenteral anticoagulants (except to maintain patency of preexisting, permanent indwelling intravenous catheters) within 10 days prior to study start and during treatment
• •Radiotherapy, chemotherapy, surgery, or any investigational drug in the 30 days before the start of treatment in this study, and/or diagnostic biopsies within 2 weeks before the start of treatment in this study
• •Previous treatment with anti-integrin therapy or anti angiogenic therapy within the last 6 months
• •Confirmed or clinically suspected brain metastases
• •Known hypersensitivity reactions to the study medication
• •History of allergic reactions to other monoclonal antibody (mAb) therapy
• •Uncontrolled hypertension (systolic blood pressure greater than (\>) 180 millimeter of mercury (mmHg), diastolic \>100 mmHg)
• •Current history of chronic daily aspirin therapy (doses of =\< 150 mg is permitted), bleeding disorders, and/or history of thromboembolic events
• •Severe peripheral vascular disease or ulceration
• •Unstable angina pectoris, or myocardial infarction within 6 months before start of study treatment, clinical significant abnormal electrocardiogram (ECG) at screening;
• •In women of childbearing potential, pregnancy (absence to be confirmed by beta human chorionic gonadotropin \[β HCG\] test, unless a subject has previously undergone hysterectomy or bilateral ovariectomy), or lactation period
• •Known alcohol or drug abuse
• •Participation in another clinical trial within the past 30 days before start of study treatment
• •All other significant diseases which, in the opinion of the principal investigator (PI), might impair the subject's tolerance of study treatment
• •Dementia, altered mental status, or any psychiatric condition that would prohibit the understanding or rendering of informed consent
• •Legal incapacity or limited legal capacity (not applicable only in rare cases)
• •Known human immuno deficiency (HIV) infection and/or active hepatitis B or C virus infections
• •Ongoing uncontrolled infections
• •Contraindications to magnetic resonance imaging (MRI)