Cardiovascular Risk Markers in Patients With Rheumatoid Arthritis: Effect of Rituximab Therapy

Inclusion Criteria

• •Able and willing to give written informed consent and comply with the requirements of the study protocol
• •Negative serum pregnancy test (for women of child bearing age)
• •Men and women of reproductive potential must agree to use an acceptable method of birth control during treatment and for twelve months (1 year) after completion of treatment.
• •IgG \& IgM levels within normal limits
• •Adequate renal function as indicated by serum creatinine measurements.
• •No previous biological use (investigational or approved) except for the three approved anti-TNF alpha therapies
• •Patients who have been treated with anti-TNF alpha therapies must be off of infliximab and adalimumab for two months before study entry and off of etanercept for one month before study entry
• •No use of phosphodiesterase type 5 inhibitors (PDE5) (i.e. Sildenafil, Tadalafil, and Vardenafil) 1 week prior to the study and during the course of the study.
• •SBP ≤ 140/90 for two months prior to study enrollment