A Pilot Study Assessing Intra-Metastasis Administration of Autologous KLH-pulsed Dendritic Cells With Tumoral Radiation Therapy in Patients With Metastatic Pancreatic Carcinoma

Exclusion Criteria

• •Ability to give informed consent
• •Previous anti-tumor vaccine therapy
• •Prior hepatic irradiation
• •Known brain metastases
• •History of prior autoimmune diseases (e.g. SLE (systemic lupus erythematosus), rheumatoid arthritis, myasthenia gravis)
• •Regular corticosteroid use within the past one year or any corticosteroid use in the four weeks preceding study entry
• •Evidence of HIV infection, AIDS, Hepatitis B or Hepatitis C infection
• •Active bacterial, fungal or viral infection
• •Pregnancy or lactation; women of childbearing potential and men must agree to use effective contraception during the course of this clinical trial
• •Uncontrolled or unstable medical conditions including angina, arrhythmias, bleeding, or thromboembolic conditions,
• •Any medical or psychiatric illness that might compromise the patients ability to tolerate treatment