Kuvan Therapy in Phenylketonuria (PKU): The Effect of Blood Phenylalanine Concentration on Kuvan Response

Exclusion Criteria

• •female patients who are pregnant or attempting to become pregnant
• •children under four years of age
• •Concurrent disease of condition that would interfere with study participation or safety such as history of neurological compromise or major medical, psychiatric or learning disorder unrelated to PKU
• •Any condition that, in the view of the Investigators, places subject at high risk of poor treatment compliance or of not completing the study
• •Use of L-Dopa, methotrexate, or other drugs that may inhibit folate metabolism