Pharmacotherapy & CM for Opioid and Cocaine Dependence

Exclusion Criteria

• •Current DSM-IV diagnosis of other drug or alcohol dependence (other than opiates, cocaine, or tobacco)
• •History of heart disease, left ventricular hypertrophy, ischemic ECG changes, chest pain, arrhythmia, hypertension.
• •History of severe renal, endocrine or hepatic diseases.
• •History of psychosis, schizophrenia, or bipolar type I.
• •History of seizure disorder.
• •Current use of over-the-counter or prescription psychoactive drugs (antidepressant, anxiolytics, antipsychotics, mood stabilizers, psychostimulants).
• •Liver function tests (SGOT,SGPT) greater than 3 times normal.
• •Current use of modafinil
• •Current suicidality
• •Pregnancy or breast-feeding;
• •Medical contraindication to treatment with study medication (e.g. for modafinil, history of heart disease, ischemic ECG changes, arrhythmia, hypertension).
• •Women of child-bearing potential must agree to use other means of birth control and to have a pregnancy test repeated at least once monthly.
• •Known allergy to modafinil or methadone.