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Effect of Sevelamer on Glucose Tolerance and Insulin Sensitivity in Patients With Chronic Renal Failure (CKD) | Clinical Trials | Clareo Health

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Effect of Sevelamer on Glucose Tolerance and Insulin Sensitivity in Patients With Chronic Renal Failure (CKD)

Study of the Effect of Treatment With Sevelamer on Glucose Tolerance and Insulin Sensitivity in Patients With Chronic Renal Failure

NCT00837655•Karolinska Institutet

View on ClinicalTrials.gov

Summary

The purpose of this study is to perform a randomized, controlled clinical trial to investigate if the phosphate binder sevelamer can improve insulin resistance and glucose handling in patients receiving maintenance hemodialysis.

Eligibility

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Male or female patients 18-80 years of age with chronic renal failure treated with maintenance HD for \>3 months.

Exclusion Criteria

•Diabetes mellitus
•Treatment with sevelamer within 3 months prior to enrollment
•Acute, clinically significant inflammation within 1 month prior to enrollment
•Pregnancy or breast-feeding
•Clinically significant obstipation or bowel obstruction
•Discontinuation of previous sevelamer treatment because of side effects
•Expected time in HD \< 1 year
•Unwillingness to undergo the investigations and follow-up required in the the protocol
•Patients who have received any investigational drug within 1 month prior to enrolment
•Participation in another study, which may interfere with the present study

Locations (2)

Sahlgrenska University Hospital

Gothenburg, Gothenburg, Sweden

Karolinska University Hospital

Stockholm, Stockholm County, Sweden

Key Dates

Start Date

January 1, 2009

Primary Completion Date

June 1, 2011

Completion Date

June 1, 2011

Last Updated

September 26, 2012

Conditions

Kidney Failure, ChronicEnd-Stage Renal DiseaseInsulin ResistanceHyperphosphatemia

Interventions

Sevelamer

DRUG

Calcium carbonate

DRUG

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 26, 2012Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effect of Sevelamer on Glucose Tolerance and Insulin Sensitivity in Patients With Chronic Renal Failure (CKD)

Inclusion Criteria

Exclusion Criteria

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