Trial of an Injectable Biologic and U0279 as Combination Therapy for Severe Plaque-Type Psoriasis

Inclusion Criteria

• •Male or female subjects 18 years of age or older.
• •Surgically sterile females. Females who have had a hysterectomy or completed menopause are allowed.
• •Affected Body Surface Area with psoriasis of ≥10%.
• •Psoriasis Global Assessment rating of "moderate to severe" or "severe".
• •Achieved mild to moderate improvement after receiving an injectable biologic therapy for at least 12 weeks.
• •A PASI score of ≥ 50 and ≤75
• •Capable of understanding and willing to provide signed and dated written voluntary informed consent (and any local or national authorization requirements) before any protocol specific procedures are performed