Memantine Treatment of Compulsive Buying

Exclusion Criteria

• •1. infrequent buying (i.e. less than one time per week) that does not meet proposed criteria for CB
• •2. unstable medical illness or clinically significant abnormalities on laboratory tests or physical examination at screen
• •3. history of seizures
• •4. myocardial infarction within 6 months
• •5. current pregnancy or lactation, or inadequate contraception in women of childbearing potential
• •6. a need for medication other than memantine with possible psychotropic effects or unfavorable interactions;
• •7. clinically significant suicidality;
• •8. current Axis I disorder determined by the SCID and SCID-compatible modules for impulse control disorders, except for nicotine dependence
• •9. lifetime history of bipolar disorder type I or II, dementia, schizophrenia, or any psychotic disorder determined by SCID
• •10. current or recent (past 3 months) DSM-IV substance abuse or dependence;
• •11. positive urine drug screen at screening
• •12. initiation of psychotherapy or behavior therapy within 3 months prior to study baseline
• •13. previous treatment with memantine
• •14. treatment with investigational medication or depot neuroleptics within 3 months, with fluoxetine within 6 weeks, or with other psychotropics within 2 weeks prior to study baseline