Early Parkinson's Disease (PD) Cross-Sectional

Exclusion Criteria

• •1. Parkinsonian symptoms not due to idiopathic (sporadic) PD, such as those that are medication induced, toxic substance induced or representative of an atypical Parkinsonian syndrome will be categorized separately.
• •2. Any unstable or uncontrolled medical or psychiatric condition.
• •3. Renal (creatinine over 1.6) or hepatic insufficiency (LFT three-fold higher than normal range), or a history of significant cardiac disease.
• •4. If there is a history or evidence of coagulopathy, on medications such as Plavix, Aggrenox, heparin, coumadin, or large doses of aspirin, must be able to remain off these medications for at least 3 days, and have stable blood coagulation values prior to any lumbar puncture (LP).
• •5. Significant dementia (MMSE\<25/30 or MOCA\<25/30) that would interfere with study procedures or the giving of informed consent for the study .
• •6. Active infections including skin, respiratory or GI infections, and HIV+ (if undergoing an LP).
• •7. Any evidence of a different neurodegenerative disorder, for example, Alzheimer's Disease or Huntington's Disease.
• •8. fMRI will not be performed is screening questionnaire identifies a reason.