Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Ipsen
Age
65–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Cognitively normal elderly (CNE)
Spontaneous memory complaint by patient,
Mini-Mental State Exam score ≥ 28.
Clinical Dementia Rating = 0.
No Diagnostic And Statistical Manual Of Mental Disorders, Fourth Edition (DSMIV) criteria for Dementia.
Memory complaints (MC) :
Spontaneous memory complaint by patient
Mini-Mental State Exam score ≥ 25
Clinical Dementia Rating 0.5.
No DSMIV criteria for Dementia.
Mild Alzheimer's Disease (AD):
Mini Mental Status Examination (MMSE) between 20 and 28 (inclusive).
Clinical Dementia Rating ≥ 1.0
DSMIV criteria for Dementia.
National Institute of Neurological and Communicative Diseases and Stroke / Alzheimer's Disease and Related Disorders Association(NINCDS/ADRDA) criteria for probable AD.
Newly diagnosed patients without treatment by Cholinesterase Inhibitors or Memantine.
≥ 65 years of age, both sex
Geriatric Depression Scale (GDS) \< 15
Informed consent signed by the patient or, if necessary by legal representative
You may not be if
Contraindication to Magnetic Resonance Imaging (MRI) and/or Positron-Emission Tomography (PET) scan
Forbidden Concomitant medications (Cholinesterase inhibitors and memantine, Specific psychoactive medications,e.g., neuroleptics, chronic anxiolytics including meprobamate, or sedative hypnotics other than benzodiazepines, Monoamine oxidase inhibitors (MAOIs) including selective MAOIs. Drugs acting on cerebral nervous system, Antidiabetes medications , Antioxidants medications, Medications known to interfere with cognitive evaluations
Significant neurological disease and psychiatric disorders/psychotic feature
