A Two-part Trial Assessing the Effects of 7α-methyl-19-nortestosterone (MENT) on Blood Pressure in Normal Men: an Open-label Pilot Study Followed by a Randomized, Double-blind, Placebo-controlled Study
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Keep this study
Lead
Population Council
Age
18–40
Sex
MALE
Healthy volunteers
Accepted
You may be eligible if
Healthy men age 18-40
Man has a sperm concentration of greater than or equal to 15 x 106/mL at screening
Man has not used hormonal therapy in the last six months
Man has a testosterone level between 270-1070 ng/dL at screening
You may not be if
Man is hypertensive, defined by
diastolic BP greater than or equal to 85 mmHg or systolic BP greater than or equal to 140 mmHg (the average of the 2nd and 3rd of 3 measurements after 10 minutes rest) at screening or
a baseline ABPM average of diastolic greater than or equal to 85 mmHg systolic greater than or equal to 130 mmHg or
is taking any hypertensive medication
Man has a BMI over 33 kg/m2
Man has active or a history of cerebrovascular or cardiovascular disease
Man has chronic or acute liver or renal disease
Man has a history of a significant psychiatric disorder, including severe depression
Man has dermatitis, psoriasis or other severe skin disorder
Man has clinically significant abnormalities of laboratory safety tests
Clareo Health | A Two-part Trial Assessing the Effects of 7α-methyl-19-nortestosterone (MENT) on Blood Pressure in Normal Men: an Open-label Pilot Study Followed by a Randomized, Double-blind, Placebo-controlled Study
