Topiramate to Aid Smoking Cessation in Alcohol Dependent Men

Exclusion Criteria

• •Subjects will be excluded if they:
• •have any clinically significant laboratory evidence of hematologic, hepatic, cardiovascular, renal, pulmonary, or thyroid disease;
• •have a current significant neurologic, hepatic, renal, gastrointestinal, pulmonary, metabolic, cardiovascular, infectious, or endocrine disease;
• •have a history of known hypersensitivity to topiramate;
• •in the investigator's judgment, pose a current suicidal or homicidal risk;
• •have taken any investigational drug within 30 days of baseline; and
• •have a current seizure disorder or a history of severe alcohol withdrawal (alcohol withdrawal seizures, hallucinations / illusions, delirium tremens).