Effect of Vyvanse on Driving in Young Adults With ADHD

Exclusion Criteria

• •Any other current psychiatric or medical condition determined to be clinically significant.
• •Current use of psychotropics or any medication with clinically significant CNS effects.
• •Individuals who have never held a valid driver's license.
• •Mental retardation (IQ \< 80).
• •Individuals with a history of substance dependence or abuse within the past 6 months. Pregnant or nursing females.
• •Known hypersensitivity to Vyvanse or amphetamines.
• •Subjects with pre-existing structural cardiac abnormalities.
• •Clinically significant abnormal screening values including:
• •Laboratory values determined to be clinically significant.
• •Consistent readings of hypertension (\>140/90) during screening period (including screening and baseline visits), defined as two or more readings (each being the average of three measurements) at a single visit with systolic blood pressure, SBP \> 140 and/or diastolic blood pressure, DBP, \> 90, and confirmed by manual reading.
• •Subjects with isolated incidences (of triplicate average BP) of SBP \> 140 and/or DBP \> 90 at baseline/week 0 visit, confirmed by manual reading, which are determined to be clinically significant.
• •Subjects with a clinically significant abnormality according to cardiology consultation (ECGs with clinically concerning intervals including PR, QTC, QRS, will be reviewed by cardiology).