Open Label Study Etanercept's Maintenance Dose in Obese Patients With Moderate to Severe Plaque Type Psoriasis

Exclusion Criteria

• •Erythrodermic, pustular, or guttate psoriasis
• •Evidence of skin conditions other than psoriasis that would interfere with study-related evaluations of psoriasis.
• •Known sensitivity to any component of the study medications.
• •Evidence of active infections such as fevers, chills, sweats, or history of untreated Lyme disease and active severe infections within 4 weeks before screening visit, or between the screening and Week 0 visits.
• •Evidence of latent or active hepatitis B infection as indicated by positive HBsAg test during the screening visit.
• •Personal or first degree family history of neurologic disease.
• •Poorly controlled medical condition including, but not limited to, unstable cardiovascular disease, poorly controlled diabetes, recent stroke, history of recurrent infections, or any other condition for which, in the opinion of the investigator, participation in the study would place the subject at risk.
• •History of any Tumor Necrosis Factor-α inhibitor use including etanercept, infliximab, and adalimumab within 4 weeks of starting study drug.
• •History of non-cutaneous malignancy within the past 5 years.
• •History of drug or alcohol abuse. Substance abuse must clearly be documented so those patients with a remote and minor history of drug/alcohol use will still have an opportunity to participate in the study.
• •Female subjects who are not postmenopausal for at least 1 year, surgically sterile, or willing to practice effective contraception during the study. Nursing mothers, pregnant women and women planning to become pregnant while on study are to be excluded.
• •Plans to receive any live vaccines during the study.
• •Evidence of photosensitivity disorder (i.e. polymorphous light eruption).
• •Known photosensitivity or known sensitivity to any of the excipients or products to be administered during dosing.
• •Current enrollment in another clinical study and treatment with another experimental drug or approved therapy for experimental use within 30 days prior to Week 0
• •Cannot commit to all the assessments required by the protocol
• •Any disorder that compromises the ability of the subject to give written informed consent and/or to comply with study procedures
• •Considered by the investigator, for any reason, to be an unsuitable candidate for study participation.
• •Cannot or do not wish to comply with the protocol washout requirements (please see section below entitled "Washout Period Prior to Week 0).