A Randomized Trial to Study Combined Pulsed Dye Laser and Rapamycin Treatment of Port Wine Stain Birthmarks.

Exclusion Criteria

• •Pregnancy.
• •Abnormal blood hematology or chemistry blood tests or urine analysis.
• •History of cancer, History of high cholesterol, lipids or liver disease
• •Allergy to macrolide drugs (e.g., erythromycin).
• •Any therapy within the previous two months to the proposed PWS treatment sites.
• •Concurrent use of known photosensitizing drugs,immunosuppressive drugs or systemic steroids,antifungals, antiepileptics, HIV protease inhibitors, cimetidine, cisapride, clarithromycin, dannzol, diltiazem, erythromycin, metoclopramide, rifabutin, rifampin, rifapentine, troleandomycin, or verapamil.