Pilot Study to Evaluate Levodopa as Treatment for Residual Amblyopia

Exclusion Criteria

• •Myopia more than -6.00 D (spherical equivalent) in either eye.
• •Current vision therapy or orthoptics
• •Ocular cause for reduced visual acuity
• •• nystagmus per se does not exclude the subject if the above visual acuity criteria are met
• •Prior intraocular or refractive surgery
• •History of narrow-angle glaucoma
• •Strabismus surgery planned within 16 weeks
• •Known allergy to levodopa-carbidopa
• •History of dystonic reactions
• •Current requirement to take oral iron supplements including multivitamins containing iron during the 8 weeks of treatment with levodopa-carbidopa
• •Current use of antihypertensive, anti-depressant medications, phenothiazines, butyrophenones, risperidone and isoniazid, non-specific monoamine oxidase inhibitors
• •Current use of medication for the treatment of attention deficit hyperactivity disorder
• •Known gastrointestinal or liver disease
• •History of melanoma
• •Known psychological problems
• •Known skin reactions to patch or bandage adhesives
• •Prior levodopa treatment
• •Current treatment with topical atropine
• •Females who are pregnant, lactating, or intending to become pregnant within the next 16 weeks.
• •* A negative urine pregnancy test will be required for all females who have experienced menarche.
• •* Requirements regarding the establishment of pregnancy and monitoring of pregnancy over the course of the study as defined by each individual Institutional Review Board may supersede these criteria.