Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Minnesota
With
National Center for Research Resources (NCRR)
High intramyocellular lipid (IMCL) content in skeletal muscle has been correlated to insulin resistance in obese subjects. Yet, endurance athletes have high intramyocellular lipid content and very low insulin resistance. There are several explanations for this paradox. This study will use a new magnetic resonance imaging technique to look at the amount of fat in the muscle and its depletion with exercise. We hypothesize that overweight subjects will have higher amounts of fat and deplete this fat more slowly than lean subjects.
Age
18–45
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Age range will be from age 18 to 45. We will be limiting the upper age range because increased age is associated with sarcopenia and alteration of fiber type.
We will define the lean trained group by a BMI of \< 24 kg/m2. We will define the overweight group as BMI \> 26 25 kg/m2.
The subjects should be participating in regular running exercise (\> 30 min/day, ≥ 5 days/week).
Weight must be stable \[+/- 5 pounds\] for at least the three months prior to the study for all participants.
You may not be if
The subjects must not be on medications that may affect lipid levels, specifically lipid lowering agents, birth control pills, or diuretics.
The subjects should not be on a high fat diet (\> 45% fat) as measured by a screening questionnaire.
The subject must not have any contraindications to magnetic resonance imaging.
