Phase II Study of Allo LMI Vaccine With IL-2 for Stable Metastatic Breast Ca

Inclusion Criteria

• •Stage IV, metastatic breast cancer, confirmed by histology or cytology.
• •* Disease must be refractory to hormone therapy for tumors that estrogen and/or progesterone receptor positive
• •* Disease must be refractory to trastuzumab for tumors that are HER2 positive
• •* Disease must be responsive to chemotherapy such that regression or at least stabilization occurs
• •* Stable disease is defined as neither sufficient shrinkage to qualify for partial response nor sufficient increase to qualify for progressive disease
• •* Measurement of regressed or stable disease must be confirmed by repeat evaluation no less than 4 weeks after the initial determination.
• •Prior systemic chemotherapy, immunotherapy, biological therapy, or investigational drug therapy is allowed if at least 4 weeks since last treatment.
• •* Patient must recover from the acute toxic effects of the treatment prior to study enrollment.
• •* There is no limit as to the number of previous chemotherapy regimens received.
• •Disease status may be measurable or non-measurable
• •Karnofsky performance status \>70%
• •Women, age 18 years or older
• •Adequate organ function within 14 days of study registration including the following:
• •* Adequate bone marrow reserve: absolute neutrophil (segmented and bands) count (ANC) ≥ 1.5 x 10\^9/L, platelets ≥75 x 10\^9/L, and hemoglobin ≥ 8.0 g/dL
• •* Hepatic: bilirubin ≤ 3 times the upper limit of normal (× ULN) for patients without tumor involvement of the liver and ≤ 5 X ULN for patients with tumor involvement of the liver; aspartate transaminase (AST) ≤ 2.5 × ULN for patients without tumor involvement of the liver and ≤ 5 X ULN for patients with tumor involvement of the liver
• •* Renal: creatinine ≤ 2.0 mg/dL
• •Must share at least one class I HLA allele with the HLA-type SKBR3 cell (class I alleles A2, A3, B14, B40, C3, C8)
• •Meets eligibility criteria for and agrees to enroll in "MT1999-06: Vaccination with Tetanus Toxoid and Keyhole Limpet Hemocyanin (KLH) to Assess Antigen-Specific Immune Responses" (IRB # 9904M01581, CPRC #2002LS032). Patients who have had tetanus toxoid within the last 7 years will not receive the tetanus vaccine component. For patients who do not know the year of their last tetanus vaccine, tetanus toxoid will be given per protocol. Subjects allergic to seafood will not be co-enrolled into MT1996-06.
• •Women of childbearing potential and their partners are required to use an effective method of contraception (ie, a hormonal contraceptive, intra-uterine device, diaphragm with spermicide, condom with spermicide, or abstinence) during the study and for 3 months after the last dose of study drug.
• •Voluntary written informed consent before performance of any study-related procedure not part of normal medical care, with the understanding that consent may be withdrawn by the subject at any time without prejudice to future medical care.
• •Concurrent malignancy other than non-melanoma skin cancer or carcinoma in situ of the cervix
• •Active infection
• •Solid organ transplantation or autoimmune diseases requiring systemic immunosuppressive therapy; however, topical or inhalational steroids are allowed.