Obese Caucasian men age 18-65 years, who are non smokers, and consuming 2 or fewer standard alcoholic drinks per day (on average over the past 5 years) will be recruited.
Obesity, for the purposes of this study, is defined by a BMI \> 30 and a waist circumference \> 102 cm.
Caucasian men only are enrolled because the cut-off points for the definition of obesity vary significantly by race.
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Men are excluded if they have any previously diagnoses or symptomatic atherosclerotic disease, or are taking any cardiovascular medication.
Men with known gallstones, history of gout, or any contraindication to MRI are also excluded.
