Phase 1 Study of Radiosensitization Using Bortezomib in Relapsed Non-Hodgkin's Lymphoma Patients Receiving Radioimmunotherapy

Exclusion Criteria

• •Patients may not be receiving any other investigational agents.
• •Patients with known brain metastases should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events.
• •History of allergic reactions attributed to compounds of similar chemical or biologic composition to bortezomib or boron.
• •Previous radiation therapy to the maximum tissue tolerance at any site.
• •Previous autologous or allogeneic stem cell transplantation.
• •Involvement of the bone marrow of \>25% by lymphoma.
• •Known involvement of the central nervous system by lymphoma. 17
• •Significant organ dysfunction, including hematologic (absolute neutrophil count \<1500, platelets \<150,000).
• •ECOG performance status \>2.
• •Uncontrolled illness including, but not limited to, ongoing or active infection,symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• •HIV infection.
• •Patient has a calculated or measured creatinine clearance of \<20 mL/minute within 14 days before enrollment.
• •Patient has ≥Grade 2 peripheral neuropathy within 14 days before enrollment.
• •Myocardial infarction within 3 months prior to enrollment or has New York Heart Association (NYHA) Class III or IV heart failure (see section 8.4), uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities. Prior to study entry, any ECG abnormality at screening has to be documented by the investigator as not medically relevant.
• •Patient has hypersensitivity to bortezomib, boron or mannitol.
• •Female subject is pregnant or breast-feeding. Confirmation that the subject is not pregnant must be established by a negative serum β-human chorionic gonadotropin (β-hCG) pregnancy test result obtained during screening. Pregnancy testing is not required for post-menopausal or surgically sterilized women.