Multicentric Study, Three Randomized Arms (R-CVP vs R-CHOP vs R-FM),for Patients With Stage II-IV Follicular Lymphoma

Inclusion Criteria

• •1. Histological DIAGNOSIS of B cell follicular lymphoma
• •2. ECOG performance status 0-2
• •3. Age range 18-75
• •4. Ann Arbor Stage: II-IV
• •5. Assessment of pathology with diagnostics biopsy
• •6. Presence of one of these criteria:
• •* B Sistemic symptoms B
• •* Extranodale pathology
• •* Cytopenia
• •* Splenomegaly
• •* Leukemia
• •* Serous effusion
• •* Ves \> 20 mm/h
• •* Ldh \> normal value
• •* Nodale or extranodal mass \> 7 cm
• •* 3 or more nodal sites \> 3 cm
• •* Adenopatic syndrome
• •7. LVEF \> 50%
• •8. Normal hepatic (bilirubin \< 1.5 mg/dl) and renal functionality (creatinin \< 2 mg/dl). If there is a lymphoma it's allow values of bilirubin \> 1.5 mg/dl and of creatinin \> 2mg/dl
• •9. No previous treatment for follicolar lymphoma unless RT-IF
• •10. Lifetime \> 6 mounth
• •11. Absence of HbsAg, HCV e HIV
• •12. Negative Coombs Test
• •13. Negative pregnant test
• •14. Cotracceptive method during the treatment and the follow three months
• •15. Formal written consent
• •16. Ability to follow the patients after the treatment for follow up