Study of MCI-196 in Chronic Kidney Disease Stage V Subjects on Dialysis With Hyperphosphatemia

Exclusion Criteria

• •Current clinically significant medical comorbidities, which may substantially compromise subject safety, or expose him/her to undue risk, or interfere significantly with study procedures and which, in the opinion of the Investigator, makes the subject unsuitable for inclusion in the study
• •serum albumin level \< 3.0g/L
• •PTH level \> 1000pg/mL
• •Hemoglobin level \< 8mg/dL
• •A History of significant gastrointestinal motility problems
• •Biliary obstruction or proven liver dysfunction
• •A positive test for HIV 1 and 2 antibodies
• •A history of substance or alcohol abuse within the last year
• •Seizure disorders
• •A history of drug or other allergy
• •using cholestyramine, colestipol or colesevelam
• •Schedule to receive a kidney transplant within the next 6 months
• •Participation in a clinical study with any experimental medication in the last 30 days or an experimental biological product within the last 90 days prior to signing of informed consent