Open Label Study of Ceftobiprole to Evaluate Pharmacokinetics in Adults Hospitalized in the ICU

Exclusion Criteria

• •Known drug allergy (including penicillin, cephalosporin, carbapenems, or other beta-lactams)
• •Renal impairment (CrCl \< 50 mL/min) or dialysis
• •History of seizures
• •ALT or AST \> 5 times upper normal limit
• •Sustained shock, unresponsive to sympathomimetics
• •Conditions that may have jeopardized adherence to the protocol (NYHA Class 4 cardiac disease, \>15% total body burn or significant third degree burn)