Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Vanderbilt University
* Subjects will be studied twice, once after receiving placebo and in a second occasion after receiving propanolol.
* An exercise capacity test with estimation of maximal oxygen consumption (VO2 max) will be done within 1 hour of receiving a pill containing placebo and that will be in appearance identical to the one for propanolol. This test will be conducted on a stationary bicycle and the effort will be gradually increased while expired air is measured during exhaustive physical work. The test will last approximately 30 minutes and be conducted in Vanderbilt's Clinical Trial Center.
* The day before and the day after the exercise test subjects will be asked to collect urine for 12 hours each time and to keep a record of how much liquid they ingest.
* Posture study tests (measurements of heart rate and blood pressure taken while lying down and at intervals for up to 30 minutes while standing) will be done the day before and the day after the exercise test.
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Meet diagnostic criteria of POTS (Raj, et al., 2005)
Age between 18-65 years
Male and female are eligible (although the majority of patients POTS are female).
Able and willing to provide informed consent
You may not be if
Presence of medical conditions that can explain postural tachycardia (e.g., dehydration, medications)
Pregnancy
Other factors which in the investigator's opinion would prevent the subject from completing the protocol.
