Arimoclomol in Sporadic Inclusion Body Myositis

Exclusion Criteria

• •Presence of any one of the following medical conditions: diabetes mellitus or patients taking anti-diabetic medications, chronic infection, chronic renal insufficiency, cancer other than skin cancer less than 5 years previously, multiple sclerosis or prior episode or central nervous system demyelination, or other chronic serious medical illnesses
• •Presence of any of the following on routine blood screening: WBC \< 3000, platelets \< 100,000, hematocrit \< 30%, BUN \> 30 mg%, creatine \> 1.5 mg%, symptomatic liver disease with serum albumin \< 3 g/dl, PT or PTT \> upper range of control values
• •Women who are pregnant or lactating
• •History of non-compliance with other therapies
• •Coexistence of other neuromuscular disease
• •Drug or alcohol abuse within the last 3 months
• •Inability to give informed consent
• •Known bleeding disorder
• •Use of potentially renal toxic drugs
• •Prior difficulties with local anesthetic