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Pre-Operative Gleason Score and PSA and Clinical Stage in Predicting the Risk of Failure in Patients Undergoing Radiation Therapy for Localized Prostate Cancer
RATIONALE: Gathering information about the Gleason score, prostate-specific antigen (PSA) level, and cancer stage from patients who have undergone radiation therapy for prostate cancer may help doctors predict how patients respond to treatment and help plan the best treatment. PURPOSE: This clinical trial is studying the Gleason score, PSA level, and cancer stage in predicting outcome in patients who have undergone radiation therapy for localized prostate cancer.
OBJECTIVES: * Evaluate the value of the pre-operative Gleason score, prostate-specific antigen level, and clinical stage in predicting the risk of failure and death in patients who have undergone radiotherapy for localized prostate cancer. OUTLINE: This is a multicenter study. Patient medical records are reviewed to collect data about pre-treatment prostate biopsy, assigned Gleason score, prostate-specific antigen level, and radionucleotide bone scan. Patients complete a Bowel Toxicity questionnaire to assess quality of life related to acute and long-term bowel toxicity after radiotherapy.
Age
18 - 120 years
Sex
MALE
Healthy Volunteers
No
University of California, San Francisco
San Francisco, California, United States
Start Date
February 25, 1993
Primary Completion Date
January 31, 2026
Completion Date
January 31, 2026
Last Updated
March 20, 2025
3,561
ACTUAL participants
medical chart review
OTHER
questionnaire administration
OTHER
quality-of-life assessment
PROCEDURE
brachytherapy
RADIATION
radiation therapy
RADIATION
Lead Sponsor
University of California, San Francisco
NCT04550494
NCT05691465
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
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