1. Cardiovascular: recent MI \< 4 wk, uncontrolled HTN \>190/110 mmHg, History of uncontrolled diabetes.

2. Symptoms of orthostasis when standing up.

3. Circulatory problems, history of vascular claudication or pitting edema.

4. Unable to fully understand instructions in order to use the equipment or the process of the study.

5. Body weight over 150 kg.

6. Lower extremity injuries that limit range of motion or function.

7. Joint problems (hip or leg) that limit range of motion or cause pain with movement despite treatment.

8. Unstable fractures.

9. Pressure sores with any skin breakdown in areas in contact with the body harness or Lokomat apparatus.

10. Chronic and ongoing alcohol or drug abuse.

11. Pre-morbid, ongoing depression or psychosis.

12. Ongoing physical therapy.

Targeted Lower Extremity Joint Training