Lead Sponsor

Bayer

Age

0 - 16 years

Sex

ALL

Healthy Volunteers

No

•Patient is \>/= 2 months of age through 16 years of age
•A parent/caregiver must sign an informed consent
•Patient must provide assent, as appropriate based on local institutional review board guidelines

•Patients presenting with the following conditions:
•* exacerbations of cystic fibrosis (CF)
•* meningitis
•* Brain abscess
•* bacterial endocarditis,
•* Bone and joint infections
•having any of the following conditions but lacking a personal history may be admitted to the trial:
•* Arthritis
•* Juvenile rheumatoid arthritis (JRA)
•* Rheumatoid arthritis (RA)
•* Systemic lupus erythematosis (SLE)
•* History of rheumatic fever
•* Psoriasis
•* Inflammatory bowel disease
•* Osteoarthritis (OA)
•Known underlying rheumatological disease, joint problems known to be associated with arthropathy.
•Patients with any pre-treatment baseline musculoskeletal exam abnormalities
•Known risk of experiencing seizures, a history of any convulsive disorders
•Requiring any concomitant therapeutic course of systemic antibacterial agent
•Participation in any industry-sponsored clinical drug development study within one month prior to this study
•Known significant liver impairment (ALAT/ASAT and/or baseline bilirubin \> 3 times upper limit of normal)
•Known significant renal insufficiency (calculated creatinine clearance of \< 30 ml/min/1.73 m²)
•Are pregnant or lactating, or are sexually active and using unreliable contraception.