Comparison of Two KADIAN 10 mg Capsules to a KADIAN 20 mg Capsule Under Fasted Conditions

Exclusion Criteria

• •History or presence of clinically significant cardiovascular, pulmonary, hepatic, renal, hematologic, gastrointestinal, endocrine, immunologic, dermatologic, neurologic, oncologic or psychiatric disease or any other condition which, in the opinion of the Investigator would jeopardize the safety of the subject or the validity of the study results.
• •Has a clinically significant abnormal finding on the physical exam, medical history, ECG or clinical laboratory results at screening.
• •History or presence of allergic or adverse response to the KADIAN or related drugs.
• •Has been on a significantly abnormal diet during the four weeks preceding the first dose of study medication.
• •Has donated blood or plasma within 30 days prior to the first dose of study medication.
• •Has participated in another clinical trial within 30 days prior to first dose of study medication.
• •Has used any over-the-counter (OTC) medication including nutritional supplements, within 7 days prior to the first dose of study medication.
• •Has used any prescription medication, except hormonal contraceptive or hormonal replacement therapy, within 14 days prior to the first dose of study medication.
• •Has been treated with any known enzyme altering drugs such as barbiturates, phenothiazines, cimetidine, carbamazepine, etc., within 30 days prior to the first dose of study medication.
• •Has smoked or used tobacco products within 60 days prior to the first dose of study medication.
• •Has a history of treatment for substance abuse (including alcohol) in the past 5 years.
• •Is a female with a positive pregnancy test result.
• •Has a positive urine screen for drugs of abuse (amphetamines, barbiturates, benzodiazepines, cocaine, cannabinoids, opiates).
• •Has had a positive test for, or has been treated for Hepatitis B, Hepatitis C or HIV.