D-Cycloserine Facilitation of Cocaine - Cue Extinction

Exclusion Criteria

• •1. Women who are pregnant, nursing or of childbearing potential and not practicing an effective means of birth control.
• •2. Subjects with evidence of or a history of significant hematological, endocrine, cardiovascular, pulmonary, renal, gastrointestinal, or neurological disease including insulin-dependent diabetes, as these conditions may affect heart rate or skin conductance measurement.
• •3. Subjects with a history of or current psychotic disorder, current major depressive disorder, bipolar affective disorder or a severe anxiety disorder as these may impact cue reactivity.
• •4. Subjects who are unwilling or unable to maintain abstinence from alcohol and other drugs of abuse (except nicotine) prior to and between the cue procedures.
• •5. Subjects meeting DSM-IV criteria for substance dependence (other than nicotine, alcohol or cocaine as appropriate) within the past 60 days.
• •6. Subjects currently taking B-blockers, anti-arrhythmic agents, psychostimulants or any other agents known to interfere with heart rate and skin conductance monitoring.
• •7. Known or suspected hypersensitivity to DCS.
• •8. Individuals taking medications that could adversely interact with study medications, including, but not limited to ethionamide, isoniazid, or amino acid supplements.
• •9. Subjects with a history of epilepsy or seizure disorder.
• •10. Subjects with significant liver impairment, as DCS may increase serum transaminases.
• •11. For fMRI participants, the need for maintenance or acute treatment with any psychoactive medication including anti-seizure medications which could potentially interfere with fMRI.
• •12. For fMRI participants, clinically significant psychiatric or medical problems that would impair participation or limit ability to participate in scan.