Cardiovascular Study of Lisdexamfetamine in Healthy and Hypertensive Attention Deficit Hyperactivity Disorder Adults

Exclusion Criteria

• •1. Pregnant or nursing females.
• •2. Clinically significant cardiovascular history, including angina, syncope, thrombosis, aneurysm, myocardial infarction, myocarditis, valvular disease, heart failure, or arrhythmia. Hypertension is exclusionary in phase one subjects.
• •3. In phase two; hypertension is not exclusionary, however blood pressure with antihypertensive treatment of ≥135/85 at baseline is exclusionary.
• •4. Clinically significant or unstable medical condition including pulmonary (asthma, edema, thrombosis), renal, hepatic, metabolic (thyroid) or neurological disorder, based upon a medical history.
• •5. Orthopedic impairment or BMI that significantly impacts or restricts exercise performance testing, per clinician judgment.
• •6. Any clinically unstable psychiatric conditions including suicidality, homicidality, bipolar disorder, psychosis.
• •7. Current (within 3 months) DSM-IV-TR criteria for current abuse or dependence with any psychoactive substance other than nicotine, including alcohol, prescription medicines and/or street drugs. In addition, subjects with clinically significant histories of dependence on alcohol, prescription medications or "street drugs" will be excluded, if such history places subjects at heightened risk, and/or may be associated with cardiovascular sequelae, based on clinician judgment.
• •8. Ongoing treatment with any psychotropic medication, including anxiolytics, antidepressants, mood stabilizers.
• •9. Use of Monoamine Oxidase Inhibitors (MAOIs) including linezolid within two weeks prior to starting study medication.
• •10. Mental retardation (IQ \< 75).
• •11. History of intolerance or allergy to LDX.
• •12. Diagnosis of glaucoma