A Study of ABT-072 in Healthy and Hepatitis C Virus Genotype 1-Infected Adults

Exclusion Criteria

• •Criteria for Healthy Adults:
• •If female, then pregnant or breast feeding
• •Positive HAV-IgM, HBs-Ag, HCV Ab or HIV Ab
• •Within 6 months of start of study, drug or alcohol abuse and use of nicotine products
• •Alcohol intake within 48 hours prior to study drug administration
• •Criteria for HCV-infected Adults:
• •Need for prescription or over-the-counter medication
• •Child Pugh score \> 5 or clinical evidence of cirrhosis
• •No other cause for liver disease other than HCV infection
• •ALT or AST \> 4 x ULN
• •Creatinine \> ULN
• •Clinically significant abnormal ECG
• •HCV RNA levels above the level of assay quantification
• •TSH values outside normal range