Effects of Modafinil in Methamphetamine Dependence

Exclusion Criteria

• •1. Women who are pregnant, nursing or of childbearing potential and not practicing an effective means of birth control.
• •2. Subjects with evidence of or a history of significant hematological, endocrine, cardiovascular, pulmonary, renal, gastrointestinal, or neurological disease as these conditions may affect heart rate or skin conductance measurement.
• •3. Subjects with a history of or current psychotic disorder or bipolar affective disorder as these may impact cue reactivity.
• •4. Subjects who are unwilling or unable to maintain abstinence from alcohol and other drugs of abuse (except nicotine) for 24 hours prior the cue procedures.
• •5. Subjects meeting DSM-IV criteria for substance dependence (other than nicotine or methamphetamine as appropriate) within the past 60 days.
• •6. Subjects currently taking B-blockers, anti-arrhythmic agents, psychostimulants or any other agents known to interfere with heart rate and skin conductance monitoring.
• •7. Known or suspected hypersensitivity to modafinil.
• •8. Individuals taking medications that could adversely interact with study medications.
• •9. Subjects with a history of epilepsy or seizure disorder.