Effect of Intravitreal Ranibizumab on Radiation Retinopathy Following Plaque Brachytherapy for Choroidal Melanoma

Exclusion Criteria

• •Pregnancy or lactation, pre-menopausal women not using contraception
• •Participation in another simultaneous medical investigation or trial
• •Patient with significantly compromised visual acuity in the study eye due to concomitant ocular conditions.
• •Patients who have undergone intraocular surgery within last 60 days.
• •Patients who have had intravitreal anti-VEGF treatment within 45 days.
• •Patients who have had intravitreal triamcinolone acetonide within 4 months.
• •Patients who have had laser within 60 days.
• •Inability to obtain photographs to document CNV (including difficulty with venous access).
• •Patient has a history of any medical condition which would preclude scheduled visits or completion of study.
• •Aphakia or absence of the posterior capsule in the study eye. Previous violation of the posterior capsule in the study eye is also excluded unless as a result of yttrium aluminum garnet (YAG) posterior capsulotomy in association with posterior chamber lens implantation..
• •History of glaucoma filtering surgery in the study eye.
• •Concurrent use of more than two therapies for glaucoma.
• •Any other condition that the investigator believes would pose a significant hazard to the subject if the investigational therapy were initiated