Study to Evaluate the Pharmacodynamics of SB-656933 in Patients With Ulcerative Colitis

Exclusion Criteria

• •The subject has a positive pre-study drug/alcohol screen.
• •A positive test for HIV, hepatitis B or C.
• •History of regular alcohol consumption within 6 months of the study
• •Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements within 7 days or 5 half-lives prior to the first dose of study medication
• •Known allergies
• •recent participation in another trial
• •recent blood donation
• •Pregnant or lactating females
• •unwillingness or inability to follow study procedures
• •consumption of red wine, seville oranges, grapefruit or grapefruit juice in last 7 seven day before study start.
• •Mild UC, Mayo endoscopic score of 0 or 1.
• •Toxic megacolon or perforation on plain abdominal Xray.
• •Crohn's Disease, indeterminate colitis, bleeding disorders, or active ulcer disease.
• •Previous colonic surgery.
• •Current or recurrent disease, other than UC, that could affect the action, absorption or disposition of the study medication, or clinical or laboratory assessments.
• •Absolute neutrophil count below 2.0x109/L.
• •A positive culture for enteric pathogens that is clinically significant, presence of clostridium difficile toxin, or with ova and parasites detected by microscopy, or has a clinical suspicion of an infectious disease of the bowel.
• •Symptomatic GI stricture within 6 months of screening or obstructive symptoms within 3 months of screening.
• •Likely to require abdominal surgery within the study period.
• •Congenital or acquired immunodeficiency, including any immunologic diseases with gastrointestinal involvement except for UC.
• •Ongoing neoplastic disease of the bowel.
• •History of prostatitis, epididymitis, epididymal cysts, structural abnormalities or testicular cancer.
• •Subjects with abnormalities of the renal tract, renal stones or history of recurrent urinary tract infections (UTI.s).
• •Subjects with any history of autoimmune hepatitis or sclerosing cholangitis. Previous inclusion in a research and/or medical protocol involving nuclear medicine, PET or radiological investigations with significant radiation burden.
• •Blood pressure persistently ≥ 140/90 mmHg at screening
• •Concurrent illness or disability that may affect the interpretation of clinical data, or otherwise contraindicates participation in this clinical study (e.g., an unstable cardiovascular, autoimmune, renal, pulmonary, hepatic, endocrine, metabolic, haematological, or neurological condition).
• •Clinically significant hepatic impairment(Evidence of cirrhosis, Clinical episodes of jaundice)
• •Current evidence of, or has been treated for a malignancy within the past 5 years.
• •BMI \<18 kg.m2 or \>35 kg/m2
• •Clinically significant renal laboratory values.
• •Has not discontinued any prohibited concomitant medication prior to the screening visit or within the protocol-specified time period.
• •Has not remained on a stable dose of any permitted concomitant medication(s) for the protocol-specified time period preceding the Screening Visit.
• •history of substance abuse