Lead Sponsor

AstraZeneca

Age

30 - 75 years

Sex

ALL

Healthy Volunteers

No

•Male or surgically sterile female of non-childbearing potential (post-menopausal, ie natural or induced menopause with last menstruation \>1 year ago and LH and FSH in the post-menopausal range, and/or have undergone hysterectomy and/or bilateral oophorectomy
•Diagnosed diabetes Mellitus patients treated with diet and exercise alone or with up to two oral anti-diabetic drugs. Stable glycemic control indicated by no changed treatment within 3 months prior to enrollment
•HbA1c ≤10.5 % at screening (HbA1c value according to international DCCT standard)

•Clinically significant illness or clinically relevant trauma, as judged by the investigator, within two weeks before the first administration of the IP
•History ischemic heart disease, stroke, transitorisk ischemic attack or symptomatic peripheral vascular disease
•Clinically significant abnormalities in clinical chemistry, hematology, or urinalysis results. Positive test of Hepatitis B surface antigen, antibodies to HIV virus and antibodies to Hepatitis C virus