History of an allergic reaction to any xanthine-containing compound.

History of seizure

History of stroke

Serious systemic infection

Sustained systolic blood pressure \>170 or \<90 mmHg

Myocardial infarction within 30 days of Day 1

Hemodynamically destabilizing arrhythmia within 30 days of Day 1

Uncorrected hemodynamically significant primary valvular disease

Known obstructive or restrictive cardiomyopathy

Cardiac surgery within 60 days prior to Day 1

Likely to undergo cardiac transplantation, device implantation, or other cardiac surgery within next three months

Evidence of malignancy within 6 months prior to Day 1.

Participation in any other investigational study of drugs or devices within 30 days prior to Day 1.

Receiving aminophylline, theophylline, pentoxifylline, dyphylline or adenosine

Presence of any clinically significant condition that might interfere with optimal safe participation in this study

Oral Tonapofylline (BG9928) in Patients With Heart Failure and Renal Insufficiency