ECOG PS of 0 or 1

Histologically confirmed NSCLC

Adequate amount of tumor (archived or fresh) for biomarker evaluation

Received one to two regimens of chemotherapy (with at least one platinum-containing)

Serum creatinine of less than 1.0 mg/dL or a 24 hour creatinine clearance of greater than 60 mL/min

Stable control of blood pressure on agents other than calcium channel blockers

Women of child-bearing potential must avoid pregnancy or maintain adequate contraception

Must be able to swallow pills and take the medications at the same time every day on an empty stomach

A Comparison Between BMS-690514 and Erlotinib in Patients Who Were Previously Treated for NSCLC