Phase II Study of Oral Panobinostat in Adult Participants With Relapsed/Refractory Classical Hodgkin's Lymphoma

Exclusion Criteria

• •1. Participant has a history of prior treatment with a deacetylase (DAC) inhibitor including panobinostat.
• •2. Participant will need valproic acid for any medical condition during the study or within 5 days prior to the first panobinostat treatment.
• •3. Participant has been treated with monoclonal antibody therapy (e.g., rituximab or anti CD-30 antibody, etc.) within 4 weeks of start of study treatment.
• •4. Participant has received chemotherapy or any investigational drug or undergone major surgery ≤ 2 weeks prior to starting study drug or whose side effects of such therapy have not resolved to ≤ grade 1.
• •5. Participant has been treated with \> 5 prior systemic lines of treatment (see Post-text supplement 2 for definitions and examples).
• •6. Participant has received prior radiation therapy ≤ 4 weeks or limited field radiotherapy ≤ 2 weeks prior to start of study treatment or whose side effects of such therapy have not resolved to ≤ grade 1.
• •7. Participant is using any anti-cancer therapy concomitantly.
• •8. Participant treated with allogeneic hematopoietic stem cell transplant who is currently on or has received immunosuppressive therapy within 90 days prior to start of screening and/or have ≥ Grade 2 graft versus host disease (GvHD).
• •9. Participant has a history of another primary malignancy ≤ 3 years before study entry, with the exception of non-melanoma skin cancer, and carcinoma in situ of uterine cervix.
• •10. Participant has a history of central nervous system (CNS) involvement with lymphoma.
• •11. Participant has impaired cardiac function including any of the following:
• •* Complete left bundle branch block or use of a permanent cardiac pacemaker, congenital long QT syndrome, history or presence of ventricular tachyarrhythmias, clinically significant resting bradycardia (\<50 beats per minute \[bpm\]), QT interval (QTcF) \> 450 milliseconds (msec) on screening electrocardiography (ECG), or right bundle branch block + left anterior hemiblock (bifascicular block).
• •* Presence of atrial fibrillation (ventricular heart rate \>100 bpm).
• •* Previous history angina pectoris or acute myocardial infarction (MI) within 6 months.
• •* Congestive heart failure (New York Heart Association functional classification III-IV) or baseline multigated acquisition (MUGA)/Echo shows left ventricular ejection fraction (LVEF) \< 45%.
• •12. Participant has any other clinically significant heart disease (e.g., uncontrolled hypertension).
• •13. Participant has an impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of panobinostat (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, obstruction, or stomach and/or small bowel resection).
• •14. Participant has unresolved diarrhea ≥ grade 2.
• •15. Participant has any other concurrent severe and/or uncontrolled medical condition(s) (e.g., uncontrolled diabetes mellitus, active or uncontrolled infection, chronic obstructive or chronic restrictive pulmonary disease including dyspnoea at rest from any cause) that could cause unacceptable safety risks or compromise compliance with the protocol.
• •16. Participant has a known history of human immunodeficiency virus (HIV) seropositivity (screening HIV testing is not required).
• •17. Participant is using medications that have a relative risk of prolonging the QT interval or of inducing Torsade de Pointes, where such treatment cannot be discontinued or switched to a different medication prior to starting study drug.
• •18. Participant is a woman who is pregnant or breast feeding, or a women of childbearing potential (WOCBP) not willing to use a double method of contraception during the study through 3 months after the end of treatment. One of these methods of contraception must be a barrier method. WOCBP are defined as sexually mature women who have not undergone a hysterectomy or who have not been naturally postmenopausal for at least 12 consecutive months (i.e., who has had menses any time in the preceding 12 consecutive months). WOCBP must have a negative serum pregnancy test at baseline.
• •19. Male participant whose sexual partner(s) are WOCBP who are not willing to use a double method of contraception, one of which includes a condom, during the study and for 3 months after the end of treatment.
• •Participants with any of the following contraindications to positron emission tomography (PET) are excluded from the \[18F\]- fludeoxyglucose (FDG) PET study (only applicable for centers participating in the PET study):
• •20. Fasting blood glucose above 200 milligrams per deciliter (mg/dL), at time of PET scan.
• •21. Inability to lay down for 60 minutes or has a history of claustrophobia.
• •22. Participant not at a participating center.