Lead Sponsor

NHS Tayside

Age

35 - 70 years

Sex

ALL

Healthy Volunteers

No

•Type 2 diabetes
•Age \>35 and \< 70
•Age of diabetes diagnosis \>35 and \<70
•White European
•Pre-SU HbA1c \<=10%
•HbA1c (on treatment) \<= 9%
•No myocardial infarction or Acute coronary syndrome in previous year
•No stroke or transient ischaemic attack in previous year
•No or stable (background) retinopathy (no unscheduled laser treatment in the last 6 months)
•eGFR \> 60mls/min
•No Proteinuria \>30mg/dl on multistix 10SG
•No active foot ulceration or infection
•Liver ALT ≤ twice the upper limit of the reference range
•Contactable by telephone

•Type 1 diabetes
•HbA1c \>10% prior to commencing SU
•HbA1c\>9% on SU treatment
•Recent MI or Stroke within last 12 months
•Pre-proliferative or proliferative retinopathy
•eGFR\<60 ml/min
•Proteinuria \>30mg/dl on multistix 10SG
•Active foot ulceration or infection
•Liver ALT \> twice the upper limit of the reference range
•Female planning to conceive within the study period
•Any other significant medical reason for exclusion as determined by the investigator