Tanezumab in Osteoarthritis of the Knee

Inclusion Criteria

• •Osteoarthritis of the knee according to ACR criteria with a Kellgren-Lawrence x-ray grade of 2.
• •Unwilling or unable to take non-opiate pain medications, for whom non-opiate pain medications have not provided adequate pain relief or are candidates for knee injections arthroplasty or replace surgery.
• •Pain level and function levels as required by the protocol at Screening and Baseline.
• •Willing to discontinue pain medications (acetaminophen will be permitted up to a certain level) before and during the study.
• •Must agree to the contraceptive requirements of the protocol if applicable.
• •Must agree to the treatment plan, scheduled visits, and procedures of the protocol.