Finding studies
Finding studies
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Lead
Hoosier Cancer Research Network
With
OUTLINE: This is a multi-center study. * Pemetrexed (Alimta) 500mg/m2 administered intravenously over approximately 10-minutes on Day 1 of a 21-day cycle x 3 cycles * Radiation will start between days -1 to 2 from day 1 of cycle 1. Day 1 radiotherapy must be a Monday, Tuesday, or Wednesday. The planned radiation dose is 60 Gy in 2.0 Gy fractions. The entire PTV, including primary tumor and areas of known nodal disease, shall receive 60 Gy at 2.0 Gy fractions, 5 fractions/week for 30 fractions over 6 weeks. Performance Status: ECOG performance status 2 Life Expectancy: Not specified Hematopoietic: * Platelets ≥ 100 K/mm3 * Absolute Neutrophil Count (ANC) ≥ 2.0 K/mm3 Hepatic: * Aspartate transaminase (AST) ≤ 2.5 x ULN. * Alanine transaminase (ALT) ≤ 2.5 x ULN. * Total bilirubin ≤ 1.5 x ULN Renal: * Calculated creatinine clearance (using Cockcroft-Gault formula) ≥ 45 cc/min Cardiovascular: * No significant history of cardiac disease. Must not have unstable angina (anginal symptoms at rest). Pulmonary: * Forced expiratory volume in 1 second (FEV1) greater than 1L
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted