Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Alexion Pharmaceuticals, Inc.
Age
18–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Generalized MG
MGFA Clinical Classification Class II, III or IVa.
QMG total score ≥12
Minimum score of two (2) in four (4) or more test items in the QMG
Able to give informed consent.
Have failed at least two immunosuppressants after one year of treatment
A positive serologic test for binding anti-acetylcholine receptor Abs at Screening and one of the following a) history of abnormal neuromuscular transmission test demonstrated by single-fiber electromyography or repetitive nerve stimulation, or b) history of positive anticholinesterase test, eg, edrophonium chloride test, or c) patient has demonstrated improvement in MG signs on acetylcholinesterase inhibitors as assessed by treating physician.
You may not be if
History of thymoma or other neoplasms of the thymus.
History of thymectomy within 12 months prior to screening.
Pregnancy or lactation
Current or chronic use of plasmapheresis/plasma exchange
IVIG treatment within 8 weeks prior to screening.
Use of etanercept within 2 months prior to screening.
Use of rituximab (RITUXAN®) within 6 months prior to screening.
