Administration of BIIB028 to Subjects With Solid Tumors

Exclusion Criteria

• •Pregnant (positive pregnancy test) or nursing women
• •Prior treatment with Hsp90 inhibitors at any time.
• •Prior antitumor therapies including prior experimental agents, approved antitumor small molecules and biologics, or radiotherapy with in 28 days or \<3 half lives (whichever is longer). In addition,prior to enrollment, all asociated toxicities must have been resolved to eligibility levels.
• •Concurrent severe or uncontrolled other medical disease (i.e, diabetes, hypertension, coronary artery disease, congestive heart failure), which in the opinion of the Investigator and/ or the Sponsor could compromise assessment of safety.
• •Use of anticoagulants, except low dose warfarin.
• •History of seizure, previous significant head trauma (e.g., associated with loss of consciousness for more than 5 minutes), abrupt discontinuation of benzodiazepines, or use of potentially epileptogenic medication