Pharmacokinetics of Implanon in Obese Women

Exclusion Criteria

• •known or suspected pregnancy
• •delivery (vaginal or cesarean) within 4 months of device insertion
• •abortion (first or second trimester) within 4 months of device insertion
• •contraindications to Implanon use
• •hemophilia
• •undiagnosed abnormal genital bleeding
• •hypersensitivity or allergy to any components of Implanon
• •personal or family history of thrombosis or thromboembolic disorders
• •hepatic tumors or active liver disease
• •known or suspected carcinoma of the breast or history of breast cancer
• •more that one cardiovascular risk factor such as hypertension or diabetes
• •known history of PCOS, diabetes, or glucose abnormality
• •present use or use within 2 months of device insertion of a CYP3A4 inducer
• •breastfeeding women
• •use of an investigational drug within 2 months of device insertion
• •use of injectable contraception within 6 months of device insertion
• •planning a pregnancy in the next 12 months
• •known HIV infection
• •smoking over the age of 35