Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
The Cleveland Clinic
Participants will be randomized into one of three study groups; Group 1 - Paravertebral Group - ropivacaine is injected near the spine before surgery. Midazolam and fentanyl are administered intravenously for sedation. Group 2 - Lidocaine/Ketamine - General anesthesia with lidocaine and ketamine administered intravenously throughout your surgery and for 60 minutes after surgery. Group 3 - General Anesthesia Alone. General anesthesia with placebo administered intravenously throughout surgery and for 60 minutes after surgery. All participants will rate their pain on a scale from 0 to 10 after surgery and on days 1 and 2 after surgery. Participants are called 3 and 6 months after surgery for pain and quality of life assessments
Age
18–75
Sex
MALE
Healthy volunteers
Not accepted
You may be eligible if
Age greater than 18 and less than 75 years
Male
Unilateral inguinal hernia scheduled for elective open repair
You may not be if
Incarcerated hernia or urgent procedure
Reoperation (recurrent hernia)
Contraindication to regional anesthesia such as:
Coagulopathy
Infection at the site of needle insertion
Pre-existing chronic pain (at any site) requiring treatment
Contraindication to any study medication (local anesthetic or ketamine)
History of significant Axis I psychiatric disease (major depressive disorder,bipolar disorder, schizophrenia, etc.)
Significant hepatic (ALT or AST \> 2 times normal) or renal (serum creatinine \> 2 mg/dl) impairment
Clareo Health | Lidocaine and Ketamine Versus Standard Care on Acute and Chronic Pain
