1. Age 18 years or older

2. Eligible for percutaneous coronary intervention

3. Patient has at least one lesion ≥50% diameter stenosis requiring PCI with stenting

4. Reference vessel diameter 2.25-4.0 mm

5. Percutaneous intervention with use of one or more of the FDA approved CypherTM stents, planned not to exceed 108 mm of stent length.

6. Target lesion is located within a native coronary artery or bypass graft

7. De novo and restenotic lesions, including ISR, radiation failure

8. Be reliable, cooperative and willing to comply with all protocol-specified procedures and follow-up

9. Able to understand and grant informed consent

The SCRIPPS DES REAL WORLD Registry